SQUID-detected MRI at 132 microT with T1-weighted contrast established at 10 microT--300 mT.

Autor: Lee SK; Department of Physics, 366 LeConte Hall, University of California, Berkeley, CA 94720, USA. Isk@socrates.berkeley.edu, Mössle M, Myers W, Kelso N, Trabesinger AH, Pines A, Clarke J
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2005 Jan; Vol. 53 (1), pp. 9-14.
DOI: 10.1002/mrm.20316
Abstrakt: T(1)-weighted contrast MRI with prepolarization was detected with a superconducting quantum interference device (SQUID). A spin evolution period in a variable field between prepolarization and detection enabled the measurement of T(1) in fields between 1.7 microT and 300 mT; T(1) dispersion curves of agarose gel samples over five decades in frequency were obtained. SQUID detection at 5.6 kHz drastically reduces the field homogeneity requirements compared to conventional field-cycling methods using Faraday coil detection. This allows T(1) dispersion measurements to be easily combined with MRI, so that T(1) in a wide range of fields can be used for tissue contrast. Images of gel phantoms with T(1)-weighted contrast at four different fields between 10 microT and 300 mT demonstrated dramatic contrast enhancement in low fields. A modified inversion recovery technique further enhanced the contrast by selectively suppressing the signal contribution for a specific value of the low-field T(1).
(Copyright 2004 Wiley-Liss, Inc.)
Databáze: MEDLINE
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