| Autor: |
Keith CT; CombinatoRx, Inc., 650 Albany Street, Boston, Massachusetts 02118, USA., Borisy AA, Stockwell BR |
| Jazyk: |
angličtina |
| Zdroj: |
Nature reviews. Drug discovery [Nat Rev Drug Discov] 2005 Jan; Vol. 4 (1), pp. 71-8. |
| DOI: |
10.1038/nrd1609 |
| Abstrakt: |
Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most drug discovery efforts search for drugs that are composed of a single chemical entity. A focus in the early drug discovery process on identifying and optimizing the activity of combinations of molecules can result in the identification of more effective drug regimens. A systems perspective facilitates an understanding of the mechanism of action of such drug combinations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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