| Autor: |
Bursuker I; Bristol-Myers Squibb Pharmaceutical Research Institute, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492., Neddermann KM, Petty BA, Schacter B, Spitalny GL, Tepper MA, Pasternak RD |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental hematology [Exp Hematol] 1992 May; Vol. 20 (4), pp. 431-5. |
| Abstrakt: |
Injection of mice with either natural bovine bone-derived or human recombinant transforming growth factor beta 1 (TGF-beta 1) resulted in a significant increase of the macrophage and macrophage-granulocyte-forming capacity of their macrophage colony-stimulating factor (M-CSF)- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent bone marrow precursor cells. The increased potential for generating granulocytes and/or macrophages from bone marrow cells of mice injected with TGF-beta 1 was associated with an increase of the number of M-CSF- and GM-CSF-dependent bone marrow colony-forming units (CFU). The effect was selective, in that in vivo applied TGF-beta 1 did not affect interleukin 3 (IL-3)-dependent CFU. The data suggest that TGF-beta may be useful in recovery of bone marrow granulocyte- and macrophage-forming potentials following depletion caused by chemo- or radiotherapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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