| Autor: |
Saada JI; Department of Internal Medicine, Division of Gastroenterology, 301 University Boulevard, Route 1058, Galveston, TX 77555-1058, USA. jsaada@utmb.edu, Barrera CA, Reyes VE, Adegboyega PA, Suarez G, Tamerisa RA, Pang KF, Bland DA, Mifflin RC, DI Mari JF, Powell DW |
| Jazyk: |
angličtina |
| Zdroj: |
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2004 Dec; Vol. 1029, pp. 379-81. |
| DOI: |
10.1196/annals.1309.023 |
| Abstrakt: |
Stromal cells, such as myofibroblasts and fibroblasts, represent a significant fraction of MHC class II-positive cells in the normal human colonic lamina propria, suggesting they may play an important role in CD4(+) T cell regulation in a tolerogenic environment. The aim of this study was to examine whether human colonic myofibroblasts (CMFs) phenotypically and functionally resemble conventional antigen-presenting cells (APCs). Our results support the hypothesis that intestinal myofibroblasts are a novel, nonprofessional APC phenotype important in modulating mucosal T cell responses. Given their strategic location, we propose that intestinal myofibroblasts play a critical role in mediating tolerance to luminal antigens. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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