| Autor: |
Aşicioglu F; The Council of Forensic Medicine, Cerrahpaşa, 34300, Istanbul, Turkey., Oguz-Savran F, Ozbek U |
| Jazyk: |
angličtina |
| Zdroj: |
Disease markers [Dis Markers] 2004; Vol. 20 (6), pp. 313-5. |
| DOI: |
10.1155/2004/643086 |
| Abstrakt: |
Paternity tests are carried out by the analysis of hypervariable short tandem repeat DNA loci. These microsatellite sequences mutate at a higher rate than that of bulk DNA. The occurrence of germline mutations at STR loci posses problems in interpretation of resulting genetic profiles. We recently analyzed 59-159 parent/child allele transfers at 13 microsatellite loci. We identified 12 mutations in 7 microsatellite loci. No mutations were occurred in other 6 loci. The highest mutation rate was observed with 5 mutations at D8S1179 locus at different alleles. The event was always single repeat related. The mutation rate was between 0 and 1.5 x 10(-2) per locus per gamete per generation. The mutation event is very crucial for forensic DNA testing and accumulation of STR mutation data is extremely important for genetic profile interpretation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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