| Autor: |
Hwang ES; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA., Szabo SJ, Schwartzberg PL, Glimcher LH |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 2005 Jan 21; Vol. 307 (5708), pp. 430-3. |
| DOI: |
10.1126/science.1103336 |
| Abstrakt: |
Cell lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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