| Autor: |
Mikhel'son MIa, Protas LL, Sokolov GP, Starshinova LA, Shelkovnikov SA |
| Jazyk: |
ruština |
| Zdroj: |
Farmakologiia i toksikologiia [Farmakol Toksikol] 1979 May-Jun; Vol. 42 (3), pp. 234-9. |
| Abstrakt: |
The action of compounds with general formula (formula: see text) on the frog heart ventricle, cat blood pressure, guinea pig ileum and frog rectus abdominis was studied. With dioxolane radicals (type F-2268) a strong muscarinomimetic action on the cat arterial blood pressure and guinea pig ileum was observed, with maximum marked action at n = 10, which was more pronounced at an even than at odd number of methylene groups. On the frog heart the compounds with an odd number of "n" elicited an atropine-like action. The compounds with pentyl radicals produced no effect on blood pressure and a weak cholinolytic effect on the frog heart. On the ileum they exhibited a cholinomimetic effect. All compounds studied acted as noncompetitive cholinolytics on the frog rectus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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