| Autor: |
Dirksen A; Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands., Langereis S, de Waal BF, van Genderen MH, Meijer EW, de Lussanet QG, Hackeng TM |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2004 Dec 23; Vol. 6 (26), pp. 4857-60. |
| DOI: |
10.1021/ol048084u |
| Abstrakt: |
[structure: see text] A bimodal target-specific contrast agent based on a cyclic peptide containing the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly efficient, chemoselective reactions, such as native chemical ligation, and gives a straightforward approach for double labeling of peptides in general. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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