| Autor: |
Aterini S; Nephrology Department, Prato Hospital, Prato, Italy. lostbat@libero.it, Fusco I, Amato M |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of nephrology [J Nephrol] 2004 Sep-Oct; Vol. 17 (5), pp. 744-6. |
| Abstrakt: |
Pure red-cell aplasia (PRCA) in recombinant human erythropoietin (rHuEpo) treated patients is a matter of growing concern. In most cases, neutralizing anti-EPO antibodies have been detected in patient serum and held responsible for the development of PRCA. We describe a 68-year-old white woman suffering from HCV-related cryoglobulinemia and chronic kidney disease on renal replacement therapy with peritoneal dialysis. Five months after the introduction of epoetin-b therapy she developed a PRCA, as shown by the bone marrow aspirate. Cryocrit rose from 5% to 15% at this time, reticulocyte count fell, while white blood cells and platelets remained within normal values. Epoetin-b therapy was discontinued and steroid treatment was started. The test for anti-erythropoietin antibodies was negative. Hemoglobin and reticulocytes progressively rose and steroid therapy was tapered and eventually stopped, when the cryocrit was 3%. We propose that a relapse in the HCV-related cryoglobulinemia might be held responsible for the erythropoietic marrow failure. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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