[Acyclic nucleoside analogues. III. Synthesis of new 2',3'-dideoxy-2',3'-didehydronucleoside analogues].

Autor: Vasilenko IA, Shamshin DV, Tsytovich AV, Kan AN, Alekseeva SG, Shvets VI
Jazyk: ruština
Zdroj: Bioorganicheskaia khimiia [Bioorg Khim] 2004 Nov-Dec; Vol. 30 (6), pp. 607-12.
DOI: 10.1023/b:rubi.0000049771.66752.74
Abstrakt: The coupling of 5-acetoxy-1,1-dimethoxypent-2-ene with cytosine and thymine trimethylsilyl derivatives, as well as the reaction of 5-acetoxy-1-bromopent-2-ene with adenine sodium salt, yielded acyclic analogues of the corresponding nucleosides containing 5'-acetoxy groups. They were deprotected with a saturated methanolic solution of ammonia to the target analogues of nucleosides, which were characterized with 1H NMR, IR, and UV spectra. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 6; see also http://www.maik.ru.
Databáze: MEDLINE