| Autor: |
De Naeyer A; Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium., Vanden Berghe W, Pocock V, Milligan S, Haegeman G, De Keukeleire D |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2004 Nov; Vol. 67 (11), pp. 1829-32. |
| DOI: |
10.1021/np040069a |
| Abstrakt: |
Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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