| Autor: |
Graddis TJ; Dendreon Corporation, 3005 1st Avenue, Seattle, WA 98121, USA. damir_vidovic@comcast.net, Diegel ML, McMahan CJ, Tsavler L, Laus R, Vidovic D |
| Jazyk: |
angličtina |
| Zdroj: |
Immunobiology [Immunobiology] 2004; Vol. 209 (7), pp. 535-44. |
| DOI: |
10.1016/j.imbio.2004.06.002 |
| Abstrakt: |
The translation machinery of a eukaryotic cell produces errors in decoding mRNA that may give rise to alternative reading frame (Arf) polypeptides. We predicted these putative aberrant translation products from the cDNA of three tumor-associated antigens (Ag): a transmembrane glycoprotein of the class I receptor tyrosine kinase erbB family HER-2, telomerase reverse transcriptase (TERT) and prostatic acid phosphatase (PAP). Immunization of mice with Arf peptide-pulsed antigen presenting cells (APC) generated potent in vivo immune protection against tumors expressing respective tumor-associated Ag. CD8+ T cells from mice immunized with HER-2 derived protective Arf peptides specifically recognized HER-2 transfected tumor cells. The strategy described here has potential for designing highly efficient novel vaccines for Ag-specific immunotherapy of human malignancies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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