[Radiation-induced rat cerebral neuron apoptosis].

Autor:	Feng WF; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. fengwf@fimmu.com, Qi ST, Qiu BH, Yang KJ, Huang LJ
Jazyk:	čínština
Zdroj:	Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA [Di Yi Jun Yi Da Xue Xue Bao] 2004 Nov; Vol. 24 (11), pp. 1289-91.
Abstrakt:	Objective: To explore the correlation between X-ray-induced rat cerebral neuron apoptosis and radiation doses. Methods: In a controlled experiment, the rats in the experimental group received X-ray radiation at different doses (2, 4, 6 and 8 Gy), and the apoptotic cerebral neurons were counted after in situ end-labeling and immunohistochemical staining. Results: X-ray radiation induced apoptosis of rat cerebral neurons, and the apoptotic rate varied with the radiation doses. Significant difference in the apoptotic rate was noted before and after radiation (P<0.0001), and between different radiation dose groups (P<0.005). The apoptotic rate differed significantly at different time points after the radiation. Conclusion: Low or medium doses of X-ray is able to induce rat cerebral neuron apoptosis depending on the radiation doses and following a definable time course.
Databáze:	MEDLINE
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