Avian cardiac tropomyosin gene produces tissue-specific isoforms through alternative RNA splicing.

Autor: Fleenor DE; Biology Department, Emory University, Atlanta, GA 30322., Hickman KH, Lindquester GJ, Devlin RB
Jazyk: angličtina
Zdroj: Journal of muscle research and cell motility [J Muscle Res Cell Motil] 1992 Feb; Vol. 13 (1), pp. 55-63.
DOI: 10.1007/BF01738428
Abstrakt: We have isolated a quail cardiac tropomyosin gene which encodes three distinct isoforms through the use of alternative exon splicing. Characterization of cDNA clones produced by this gene indicate that the gene encodes a unique 284 amino acid cardiac tropomyosin isoform, along with a 248 amino acid cytoskeletal and 284 amino acid smooth muscle isoforms. Northern analyses indicate that the gene is primarily expressed in cardiac muscle, with only minor expression of the cytoskeletal and smooth muscle transcripts.
Databáze: MEDLINE
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