| Autor: |
Hawrylyshyn KA; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA., Michelotti GA, Cogé F, Guénin SP, Schwinn DA |
| Jazyk: |
angličtina |
| Zdroj: |
Trends in pharmacological sciences [Trends Pharmacol Sci] 2004 Sep; Vol. 25 (9), pp. 449-55. |
| DOI: |
10.1016/j.tips.2004.06.011 |
| Abstrakt: |
Alpha1-adrenoceptors are G-protein-coupled receptors that bind catecholamines. Sixteen distinct human alpha1A-adrenoceptor isoforms have been identified from human tissues, including five full-length and 11 truncated versions. An updated scheme for the identification of alpha1A-adrenoceptor splice variants is proposed. Given the established roles of alpha1-adrenoceptors in benign prostatic hyperplasia, myocardial hypertrophy and other cardiovascular disorders, elucidation of the biological significance of the signaling diversity and potential pharmacological roles of alpha1A-adrenoceptor splice variants are important areas of future research. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect