[Capecitabine combined with TACE for advanced liver cancer].

Autor:	Li L; Department of Hepatoductopancreas, Second Hospital, Kunming Medical College, Kunming 650101, China. ynkmlili@yahoo.com.cn, Sun F, Chen AJ, Li XY, Hu MD, Ran JH, Tang JH
Jazyk:	čínština
Zdroj:	Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2004 Sep; Vol. 26 (9), pp. 565-6.
Abstrakt:	Objective: To evaluate the clinical efficacy of capecitabine combined with transcatheter arterial chemoembolization (TACE) for advanced liver cancer. Methods: Forty-nine patients with liver cancer were retrospectively divided into two groups: Treatment group, on the basis of TACE, 23 patients received oral capecitabine at 2500 mg/m(2), twice-daily for 14 days followed by 7-day rest period and repeated in every three week intervals for more than two cycles. Control group, 26 patients received TACE only at 2-month intervals for at least two cycles. Results: In capecitabine and TACE group: there were 1 CR, 14 PR, 5 SD and 3 PD; the overall response rate was 65.2%; the AFP and tumor reduction rates were 68.8% and 73.9%; the median survival time was 11.9 months. In the TACE only group: there were 0 CR, 7 PR, 12 SD and 7 PD; the overall response rate was 26.9%; the AFP and tumor reduction rates were 31.6 % and 30.8%; the median survival time was 8.3 months. The most common side-effects of capecitabine were hand-foot syndrome and diarrhea. Conclusion: Capecitabine combined with TACE is safe and effective for advanced liver cancer.
Databáze:	MEDLINE
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