| Autor: |
Bantsiele GB; Laboratoire de Pharmacologie, Faculté de Médecine, Université de Rennes 1, CS34317, 35043 Rennes, France., Bentué-Ferrer D, Amiot N, Allain H, Bourin M, Reymann JM |
| Jazyk: |
angličtina |
| Zdroj: |
Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2004 Dec; Vol. 18 (6), pp. 685-92. |
| DOI: |
10.1111/j.1472-8206.2004.00295.x |
| Abstrakt: |
We used two validated psychopharmacological methods, the forced swimming test (FST 20 min and 5 min) and the elevated plus-maze (EPM), to quantify depression-like and anxiety-like behavior induced by transient global cerebral ischemia in the rat. We also validated use of these methods for the study of antidepressant (imipramine) and anti-anxiety drugs (diazepam). Twelve days after surgery to provoke transient global ischemia, spontaneous motor activity was 40% higher in ischemic rats than in sham-operated controls. Duration of immobility during the FST 20 min and 5 min was 28 and 30% shorter, respectively, than in controls. Treatment with imipramine (3 x 30 mg/kg i.p.) induced a significantly shorter duration of immobility during the FST 5 min, but with no difference between ischemia and control rats. The EPM demonstrated that ischemia did not induce any change in the six behavior parameters measured. Diazepam (1.5 mg/kg i.p.) induced significant anxiolytic effects which were similar in ischemic and sham-operated animals. Both tests failed to demonstrate perturbed performance but conversely, these findings did disclose the sensitivity of ischemia-exposed rats to the action of imipramine and diazepam, demonstrating the usefulness of these tests as psychopharmocological tools for evaluating the effect of psychotropics in the ischemic rat. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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