Prenatal glucocorticoid exposure and postnatal adaptation in premature newborn baboons ventilated for six days.

Autor: Smith LM; Department of Pediatrics, Harbor-UCLA Research and Education Institute, University of California, Los Angeles School of Medicine, Harbor-UCLA Medical Center, Torrance, Calif, USA. smith@gcrc.rei.edu, Altamirano AK, Ervin MG, Seidner SR, Jobe AH
Jazyk: angličtina
Zdroj: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2004 Nov; Vol. 191 (5), pp. 1688-94.
DOI: 10.1016/j.ajog.2004.04.010
Abstrakt: Objective: Renal and cardiovascular function is improved during the first 24 hours of life in preterm ventilated baboons exposed to prenatal betamethasone (BETA). We hypothesized BETA-induced effects would be sustained through day 6 of life. Study design Pregnant baboons received saline or BETA (6 mg) 48 and 24 hours before preterm delivery at 125 days' gestation. The newborn baboons were ventilated for 6 days, and assessed for renal, cardiovascular, and endocrine function.
Results: Mean arterial blood pressure (MAP) and glomerular filtration rate (GFR) values 24 hours after delivery were higher in the BETA group. Kidney Na, K-ATPase activity was higher in the BETA group by day 6. All other measures were similar in both groups by day 6.
Conclusion: Prenatal BETA exposure in the premature baboon: (1) increases MAP and GFR on day 1 without measurable effects by day 6 and (2) increases kidney Na, K-ATPase activity.
Databáze: MEDLINE
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