Solid-phase synthesis of N-bi- and N-terarylpiperazines via three different and consecutive palladium-catalyzed cross-coupling reactions.

Autor: Ruhland T; Department of Medicinal Chemistry, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark. tr@lundbeck.com, Svejgaard L, Rasmussen LK, Andersen K
Jazyk: angličtina
Zdroj: Journal of combinatorial chemistry [J Comb Chem] 2004 Nov-Dec; Vol. 6 (6), pp. 934-41.
DOI: 10.1021/cc0499439
Abstrakt: Novel nonsymmetrical N-bi- and N-terarylpiperazines were synthesized on solid phase via three consecutive palladium-catalyzed cross-coupling reactions in which C-N, C-B, and C-C bonds are formed consecutively.
Databáze: MEDLINE