| Autor: |
el-Shanti H; Department of Pediatrics, University of Iowa College of Medicine, Iowa City., Bell WE, Waziri MH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of child neurology [J Child Neurol] 1992 Jan; Vol. 7 (1), pp. 29-34. |
| DOI: |
10.1177/088307389200700105 |
| Abstrakt: |
Epidermal nevus syndrome is one of the sporadic congenital hamartoses in which neurologic abnormalities have been frequently reported. We report two cases with severe primary brain involvement, seizures, mental retardation, and facial hemihypertrophy. We emphasize the superiority of magnetic resonance imaging over other radiographic studies in outlining the primary central nervous system anomalies associated with this syndrome. Although attempts were made to distinguish between several variants of epidermal nevus syndrome, it is clear that these are one entity. Proteus syndrome, encephalocraniocutaneous lipomatosis, and epidermal nevus syndrome have several overlapping phenotypic features. We suggest that they represent a phenotypic continuum, which in turn suggests a common pathogenetic process. While the cause of these syndromes is unknown, observations point to a somatic mutation leading to variable patterns of mosaicism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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