| Autor: |
Kawasaki Y; Department of Pediatrics, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima 960-1295, Fukushima City, Japan. tomo@fmu.ac.jp, Suzuki J, Takahashi A, Isome M, Nozawa R, Suzuki H |
| Jazyk: |
angličtina |
| Zdroj: |
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2005 Jan; Vol. 20 (1), pp. 96-8. Date of Electronic Publication: 2004 Oct 21. |
| DOI: |
10.1007/s00467-004-1647-1 |
| Abstrakt: |
There have been reports of the use of mizoribine (MZB) oral pulse therapy for the treatment of systemic lupus erythematosus. We report its efficacy in a 9-year-old girl with steroid- and cyclosporine-dependent nephrotic syndrome (NS). The patient experienced relapses of NS when prednisolone was tapered to 20 mg/day after discontinuing cyclosporine due to biopsy proven toxicity. When methylprednisolone pulse therapy combined with prednisolone therapy (40 mg/day) failed to result in a complete remission after 3 weeks, oral MZB pulse therapy (total dose of 500 mg, 10 mg/kg per day in three divided daily doses twice a week) was given. This therapy was continued for 9 months and resulted in complete remission of the NS for 6 months despite the discontinuation of prednisolone. The serum concentration of MZB was above 2.5 microg/ml for about 10 h (from 3 h after the first dose of MZB to 2 h after the final dose). Thus, our results suggest that this regimen may be effective for patients with steroid-dependent NS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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