| Autor: |
Alexander HL; Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd., Atlanta, GA 30322, USA. heather.alexander@hhs.gov, Rasmussen AW, Stojiljkovic I |
| Jazyk: |
angličtina |
| Zdroj: |
Infection and immunity [Infect Immun] 2004 Nov; Vol. 72 (11), pp. 6743-7. |
| DOI: |
10.1128/IAI.72.11.6743-6747.2004 |
| Abstrakt: |
It has been proposed that increased phase variation frequencies in Neisseria meningitidis augment transmissibility and invasiveness. A Himar1 mariner transposon mutant library was constructed in serogroup A N. meningitidis and screened for clones with increased phase variation frequencies. Insertions increasing the frequency of slippage events within mononucleotide repeat tracts were identified in three known phase variation-modulating genes (mutS, mutL, and uvrD), as well as six additional loci (pilP, fbpA, fbpB, NMA1233, and two intergenic regions). The implications of these insertion mutations are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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