| Autor: |
Martelo OJ; Department of Medicine, University of Cincinnati College of Medicine, Ohio., Omura GA, Gordon DS, Raney M, Bartolucci AA, Vogler WR |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of clinical oncology [Am J Clin Oncol] 1992 Feb; Vol. 15 (1), pp. 61-8. |
| DOI: |
10.1097/00000421-199202000-00012 |
| Abstrakt: |
One hundred ninety-two evaluable patients were treated on a multicenter protocol for adult acute lymphoid leukemia to determine in a prospective randomized fashion if late intensification chemotherapy beginning after about six months of treatment would improve remission duration and survival. The complete remission rate was 60%. The median remission duration was 13.5 versus 25.9 months (P = 0.31) for standard maintenance therapy and late intensification, respectively, and the median survival was 17.5 versus 34.7 months (P = 0.19) respectively. Although there was a suggestion that the late intensification strategy was helpful, relapse proved to be common during the early phases of treatment; thus, insufficient numbers of patients were available at the randomization point to conclusively address the possible value of late intensification. Intensive therapy earlier in remission should be evaluated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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