Treatment of locally recurrent rectal cancer, results and prognostic factors.

Autor: Reerink O; Department of Radiation Oncology, University Hospital Groningen, Groningen, The Netherlands., Mulder NH, Botke G, Sluiter WJ, Szabó BG, Plukker JT, Verschueren RC, Hospers GA
Jazyk: angličtina
Zdroj: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2004 Nov; Vol. 30 (9), pp. 954-8.
DOI: 10.1016/j.ejso.2004.07.013
Abstrakt: Purpose: Assessment of the results and prognostic factors in patients with locally recurrent rectal cancer treated with curative intent.
Patients and Methods: Forty patients with an isolated pelvic recurrence of rectal cancer were studied retrospectively. The treatment consisted of radiotherapy alone or combined with chemotherapy and/or surgery performed between January 1992 and July 2001. Radiotherapy was given with a 3-4 fields technique (6-15 MV), five times a week. The median radiation dose was 50 Gy (range 25-66.6 Gy). Twenty-five patients underwent salvage surgery. Five patients were treated with concomitant chemotherapy (5-fluoro-uracil/leucovorin) (5FU/LV) during the 1st and 5th week of radiotherapy.
Results: Twenty-two of the 40 patients were male. The local recurrence free survival after 3 and 5 years, respectively, was 49 and 39%. Male gender was the only independent factor associated with failure of local control. The 3 and 5-year overall survival of the total group was 36 and 19%, respectively, with a median survival of 26 months.
Conclusion: In a selection of patients in the treatment of locally recurrent rectal cancer valuable local palliation if not cure, can be reached. A multimodality approach seems to offer the best chances in this threatening situation.
Databáze: MEDLINE
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