| Autor: |
Martins de Lima T; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Av. Professor Lineu Prestes, 1524, Butantã, São Paulo, SP 05508-900, Brazil., de Oliveira Rodrigues L, Bengtson MH, Sogayar MC, Bezerra CN, Rebouças NA, Curi R |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS letters [FEBS Lett] 2004 Oct 22; Vol. 576 (3), pp. 320-4. |
| DOI: |
10.1016/j.febslet.2004.09.025 |
| Abstrakt: |
In this study, the effect of oleic acid (50 microM) on gene expression of Jurkat cells (human T lymphocytes cell line) was examined using the suppressive subtractive hybridization approach. This technique allowed us to identify genes with higher or lower expression after cell treatment with oleic acid as compared to untreated cells. Oleic acid upregulated the expression of the translation elongation factor alpha 1 and ATP synthase 8 and downregulated gp96 (human tumor rejection antigen gp96), heat-shock protein 60 and subtilisin-like protein 4. These results suggest that oleic acid, at plasma physiological concentration, can regulate the expression of important genes to maintain the machinery that ensures cell functioning. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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