Haplotypes of the beta2-adrenergic receptor gene are associated with essential hypertension in a Singaporean Chinese population.
| Autor: | Lee YW; Division of Clinical Pharmacology, Department of Medicine, National University of Singapore., Oh VM, Garcia E, Taylor EA, Wu H, Yap EP, Kazeem GR, Caulfield MJ, Munroe PB |
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| Jazyk: | angličtina |
| Zdroj: | Journal of hypertension [J Hypertens] 2004 Nov; Vol. 22 (11), pp. 2111-6. |
| DOI: | 10.1097/00004872-200411000-00012 |
| Abstrakt: | Objective: To investigate the relation between the gene encoding the beta2-adrenergic receptor (B2AR) and essential hypertension in a Singaporean Chinese cohort. Methods: Three single nucleotide polymorphisms (SNPs) were genotyped in 190 cases and 323 controls, and eight haplotypes were determined and tested for association using the likelihood test statistic. Results: We observed a significant difference in haplotype frequency distributions between the cases and the controls (P <0.00001). A logistic regression model fitted to the data supported this finding. Conclusion: The results suggest that variants at the B2AR locus may play a role in the pathophysiology of hypertension in this population. |
| Databáze: | MEDLINE |
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