[Risk markers for insulin-dependent diabetes mellitus and duration of exposure to gluten in celiac patients].
| Autor: | Verbeke S; Unidad de Gastroenterología, División de Nutrición Humana, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Macul 5540, Santiago, Chile. sverbeke@globalcom.cl, Cruchet S, Gotteland M, Ríos G, Hunter B, Chávez E, Brunser O, Araya M |
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| Jazyk: | Spanish; Castilian |
| Zdroj: | Revista medica de Chile [Rev Med Chil] 2004 Aug; Vol. 132 (8), pp. 979-84. |
| DOI: | 10.4067/s0034-98872004000800010 |
| Abstrakt: | Background: Celiac patients are at high risk of developing insulin-dependent diabetes mellitus, a condition that has a long pre-diabetic period. During this lapse, anti-islet cell antibodies serve as markers for future disease. This may be related with the duration of the exposure to gluten. Aim: To test the hypothesis that long term adherence to a gluten free diet decreases the frequency of risk markers for insulin dependent diabetes mellitus during adolescence and early adulthood. Patients and Methods: 158 celiac patients were classified as: G1, (n=30 patients) studied at the time of diagnosis; G2 (n=97 patients) exposed to gluten as a result of non compliance with the gluten free diet and, G3 (n=31 patients) who had maintained a long term, strict gluten free diet. Isotype IgG anti-islet cell antibodies were detected by indirect immunofluorescence using monkey pancreas, results were reported in Juvenile Diabetes Foundation (JDF) units. Results: Celiac patients exposed to a gluten containing diet had a significantly higher prevalence of anti-islet cell antibodies than those who had been exposed only briefly (p < 0.017). In addition, a significantly higher prevalence of anti-islet cell antibodies was observed in those patients whose exposure to gluten was longer than 5 years than in those whose exposure was shorter (p < 0.02). Conclusions: Celiac patients long exposed to gluten have a significantly higher prevalence of anti-islet cell antibodies than those exposed for a short period. This fact supports the hypothesis that the development of these antibodies is associated with the length of the exposure to gluten. |
| Databáze: | MEDLINE |
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