[Dysaggregants effect of platelet aggregation in patients with non-ST segment elevation acute coronary syndrome].
Autor: | Poponina TM, Kapilevich NA, Kisteneva IV, Markov VA, Novitskiĭ VV |
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Jazyk: | ruština |
Zdroj: | Terapevticheskii arkhiv [Ter Arkh] 2004; Vol. 76 (8), pp. 18-22. |
Abstrakt: | Aim: To study efficacy of treating patients with acute coronary syndrome (ACS) without ST segment elevation (STSE) with platelet dysaggregation drugs (aspirin, cardiomagnil, clopidogrel). Material and Methods: 78 ACS without STSE were randomized into five groups: group 1 patients (n = 17) received no dysaggregants; patients of group 2 (n = 26) received aspirin in the dose 250 mg on the day of admission and then 125 mg/day; group 3 was given cardiomagnil (150 mg on the day of admission and then 75 mg/day, n = 17); group 4--clopidogrel 75 mg/day (n = 7); group 5--combination of clopidogrel 75 mg/day with cardiomagnil 75 mg/day (n = 11). All the patients were administered fraxiparin 86 IU/kg sc each 12 hours for 5-8 days. Results: Group 1 patients showed platelet hyperaggregation, platelet aggregation decreased in groups 2, 3 and 4 (6 patients of group 1 were resistant to aspirin). The highest antiaggregation effect was achieved in group 5. Conclusion: Control over antiaggregation treatment in patients with ACS without STSE by monitoring of platelet function open broad opportunities for selection of effective individual therapy. |
Databáze: | MEDLINE |
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