| Autor: |
Hicks AE; Cardiovascular Research Unit, University of Sheffield, United Kingdom., Abbitt KB, Dodd P, Ridger VC, Hellewell PG, Norman KE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of leukocyte biology [J Leukoc Biol] 2005 Jan; Vol. 77 (1), pp. 59-66. Date of Electronic Publication: 2004 Oct 05. |
| DOI: |
10.1189/jlb.1103573 |
| Abstrakt: |
Selectins and their ligands support leukocyte rolling, facilitating the subsequent firm adhesion and migration that occur during inflammation. TBC-1269 (Bimosiamose), a structural mimetic of natural selectin ligands, inhibits P-, E-, and L-selectin in vitro, has anti-inflammatory effects in vivo, and recently underwent phase II clinical trials for childhood asthma and psoriasis. We studied whether the anti-inflammatory effects of TBC-1269 could be related to leukocyte rolling in vivo. Although TBC-1269 inhibited rolling of a murine leukocyte cell line on murine P-selectin in vitro and thioglycollate-induced peritonitis in vivo, it did not alter leukocyte rolling in mouse cremaster venules. TBC-1269 reduced neutrophil recruitment in thioglycollate-induced peritonitis in wild-type and P-selectin-/- mice but not in E-selectin-/- mice. We suggest that the in vivo effects of TBC-1269 may be mediated through E-selectin but do not appear to involve leukocyte rolling. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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