| Autor: |
Hogan RJ; Department of Homeland Security, Southern Research Institute, Birmingham, AL, USA., Gao G, Rowe T, Bell P, Flieder D, Paragas J, Kobinger GP, Wivel NA, Crystal RG, Boyer J, Feldmann H, Voss TG, Wilson JM |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of virology [J Virol] 2004 Oct; Vol. 78 (20), pp. 11416-21. |
| DOI: |
10.1128/JVI.78.20.11416-11421.2004 |
| Abstrakt: |
Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the lungs and the development of self-limited bronchiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Stat1 demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus in lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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