| Autor: |
Shiflett MW; Department of Psychology, 212 Uris Hall, Cornell University, Ithaca NY 14853, USA., Rankin AZ, Tomaszycki ML, DeVoogd TJ |
| Jazyk: |
angličtina |
| Zdroj: |
Proceedings. Biological sciences [Proc Biol Sci] 2004 Oct 07; Vol. 271 (1552), pp. 2043-8. |
| DOI: |
10.1098/rspb.2004.2823 |
| Abstrakt: |
Food-storing birds demonstrate remarkable memory ability in recalling the locations of thousands of hidden food caches. Although this behaviour requires the hippocampus, its synaptic mechanisms are not understood. Here we show the effects of cannabinoid receptor (CB1-R) blockade on spatial memory in food-storing black-capped chickadees (Poecile atricapilla). Intra-hippocampal infusions of the CB1-R antagonist SR141716A enhanced long-term memory for the location of a hidden food reward, measured 72 h after encoding. However, when the reward location changed during the retention interval, birds that had received SR141716A during initial learning showed impairments in recalling the most recent reward location. Thus, blocking CB1-R activity may lead to more robust, long-lasting memories, but these memories may be a source of proactive interference. The relationship between trace strength and interference may be important in understanding neural mechanisms of hippocampal function in general, as well as understanding the enhanced memory of food-storing birds. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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