The prebiotic synthesis of deoxthymidine oligonucleotides. II. Comparison of condensing agents.

Autor: Odom DG, Brady JT
Jazyk: angličtina
Zdroj: Journal of molecular evolution [J Mol Evol] 1975 Nov 04; Vol. 6 (3), pp. 199-207.
DOI: 10.1007/BF01732356
Abstrakt: A reaction which oligomerizes nucleotides under possible prebiotic conditions has been characterized. Nucleoside monophosphate in the presence of cyanamide at acid pH condenses to form dithymideine pyrophosphate and phosphodiester bonded compounds. Imidazole compounds and activated precursors such as nucleoside triphosphate are not necessary for this ologomerization reaction which produces primarily cyclic ologonucleotides.
Databáze: MEDLINE