| Autor: |
Kappel JC; Department of Chemistry, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455, USA., Yokum TS, Barany G |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of combinatorial chemistry [J Comb Chem] 2004 Sep-Oct; Vol. 6 (5), pp. 746-52. |
| DOI: |
10.1021/cc049973b |
| Abstrakt: |
An efficient and advantageous solid-phase strategy has been developed to synthesize 1,3,4-thiadiazolium-2-aminides. The title compounds were prepared in parallel fashion according to the following compact route: (i) anchoring of aromatic aldehydes to the solid support; (ii) solution preparation of 1,4-disubstituted thiosemicarbazides from hydrazines plus isothiocyanates; (iii) trimethylsilyl chloride-promoted cyclization between the resin-bound aldehydes and 1,4-disubstituted thiosemicarbazides; and (iv) removal of the products from the solid support by acid treatment. The products (17 made in all) were cleaved with high initial purities (90-98%) and obtained in generally good isolated yields (53-94%, with one exception). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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