Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema.

Autor: Newson RB; Department of Public Health Sciences, Guy's, King's and St Thomas' School of Medicine, King's College, London, UK., Shaheen SO, Henderson AJ, Emmett PM, Sherriff A, Calder PC
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2004 Sep; Vol. 114 (3), pp. 531-7.
DOI: 10.1016/j.jaci.2004.05.010
Abstrakt: Background: Few studies have explored whether fetal exposure to n-6 and n-3 fatty acids influences the inception of atopic disease.
Objective: To assess prenatal fatty acid exposures as predictors of early childhood wheezing and eczema.
Methods: In the Avon Longitudinal Study of Parents and Children, late pregnancy maternal blood samples and umbilical cord blood samples were assayed for n-6 and n-3 fatty acids (percentage of total red cell phospholipid), and mothers were asked about wheezing and eczema in their children. We measured associations of 11 n-6 and n-3 fatty acid exposures with wheezing at 30 to 42 months, with wheezing patterns defined by presence (+) or absence (-) of wheezing during 2 periods, 0 to 6 months and 30 to 42 months (transient infant, +/-; later-onset, -/+; persistent, +/+; n=1191 and n=2764 for cord and maternal analyses, respectively), and with eczema at 18 to 30 months (n=1238 and n=2945 for cord and maternal analyses, respectively).
Results: In cord blood red cells, the ratio of arachidonic:eicosapentaenoic acid was positively associated with eczema (adjusted odds ratio [OR] per doubling, 1.14; 95% CI, 1.00-1.31; P=.044), the ratio of linoleic acid:alpha-linolenic acid was positively associated with later-onset wheeze (OR, 1.30; CI, 1.04-1.61; P=.019), and the ratio of alpha-linolenic acid:n-3 products was negatively associated with later-onset wheeze (OR, 0.86; CI, 0.75-0.99; P=.040). However, these associations were no longer significant after adjusting for multiple comparisons.
Conclusions: It seems unlikely that fetal exposure to n-6 and n-3 fatty acids is an important determinant of early childhood wheezing and atopic disease.
Databáze: MEDLINE
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