| Autor: |
Krestow M; Department of Physiology, University of Toronto, Ontario, Canada., Lum ZP, Tai IT, Sun AM |
| Jazyk: |
angličtina |
| Zdroj: |
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology [Biomater Artif Cells Immobilization Biotechnol] 1992; Vol. 20 (1), pp. 43-51. |
| DOI: |
10.3109/10731199209117857 |
| Abstrakt: |
This study examines the effect of pancreatic islet transplants on the streptozotocin(STZ)-associated toxicity in diabetic animals. Mice with STZ-induced diabetes were implanted with microencapsulated or free rat islets. The effectiveness of the transplant was evaluated in terms of: (A) blood glucose monitoring, (B) determination of subset levels of the helper and cytotoxic T-lymphocytes, and (C) STZ-associated mortality. The experimental results demonstrate that the transplanted islets can quickly restore normoglycemia. The restoration of normal blood glucose levels is accompanied by a significant increase in proportions of helper and cytotoxic T-cells. There was no mortality in the transplant recipients as a result of the STZ administrations, whereas a significant mortality was observed in the control group of mice. No significant differences between the encapsulated and free islet transplant recipients were observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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