| Autor: |
Kang Q; Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA., An YH, Butehorn HF 3rd, Friedman RJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 1998 Aug; Vol. 9 (8), pp. 463-73. |
| DOI: |
10.1023/a:1008871401543 |
| Abstrakt: |
Inflammatory knee arthritis was induced by intraarticular injection of carrageenan twice a week for a total of 6 weeks in New Zealand White rabbits and the effects of the arthritis on the morphological and mechanical properties of the adjacent femur and tibia were evaluated 8 weeks after the first injection. Carrageenan-induced knee arthritis resulted in severe osteopenic changes and a dramatic decrease in bone strength of the entire ipsilateral femur and tibia, including the femoral head and distal tibia, but not the contralateral femur and tibia and the remote humerus. The osteoporotic changes of the adjacent bones of the inflammatory arthritic knee are the basis for the reduced mechanical strength of these bones. These findings may have clinical significance with regard to the mechanisms and consequences of osteoporotic changes in patients with rheumatoid arthritis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink