Changes in left ventricular dimensions and systolic function in 100 mildly hypertensive men during one year's treatment with atenolol vs. hydrochlorothiazide and amiloride (Moduretic): a double-blind, randomized study.

Autor: Otterstad JE; Medical Department, Vestfold Central Hospital, Toensberg, Norway., Froeland G, Wasenius Soeyland AK, Knutsen KM, Ekeli T
Jazyk: angličtina
Zdroj: Journal of internal medicine [J Intern Med] 1992 May; Vol. 231 (5), pp. 493-501.
DOI: 10.1111/j.1365-2796.1992.tb00965.x
Abstrakt: In a randomized double-blind study to compare the effect of atenolol vs. hydrochlorothiazide and amiloride (Moduretic) on left ventricular dimensions and systolic function, 100 hypertensive men were followed up during 1 year of treatment, 50 subjects being randomized to each drug. Echocardiography was performed at baseline, and after 3 and 12 months of treatment. A significant reduction in left ventricular mass with atenolol was paralleled by a decrease in left ventricular wall thickness and an increase in stroke volume. A similar reduction of left ventricular mass with Moduretic without a change in relative wall thickness and a decrease in stroke volume was observed. Cardiac output decreased in both groups.
Databáze: MEDLINE
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