Laser Doppler flow and brain tissue PO2 after cortical impact injury complicated by secondary ischemia in rats treated with arginine.
| Autor: | Mendez DR; Department of Pediatrics/Emergency Medicine, Baylor College of Medicine, Houston, Texas 77030, USA. drmendez@texaschildrenshospital.org, Cherian L, Robertson CS |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of trauma [J Trauma] 2004 Aug; Vol. 57 (2), pp. 244-50. |
| DOI: | 10.1097/01.ta.0000103983.22362.67 |
| Abstrakt: | Background: Traumatic brain injury (TBI) makes the brain susceptible to secondary insults such as ischemia. This study tested the hypothesis that L-arginine would increase regional CBF (rCBF) and brain tissue PO2 (PbtO2) at the injury site. Methods: A secondary insult model was employed in rodents. rCBF was measured with laser doppler flowmetry (LDF) and PbtO2 with a PO2 catheter at the impact site. Animals were randomized to receive L-arginine, D-arginine or saline intravenously, 5 minutes after impact. Results: In animals who received L-arginine, the percentage rCBF from baseline (%CBF) was higher at the impact site after impact (p < 0.001), during bilateral carotid occulation (BCO) (p = 0.001) and during reperfusion (p = 0.032). In contrast, PbtO2 was not significantly increased throughout the experiment for the L-arginine group. Conclusions: Administration of L-arginine increased rCBF in the injured brain tissue, and resulted in better preservation of CBF during BCO than D-arginine and saline. |
| Databáze: | MEDLINE |
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