| Autor: |
Mitchell SS; Nereus Pharmaceuticals, Inc., 10480 Wateridge Circle, San Diego, California 92121, USA., Nicholson B, Teisan S, Lam KS, Potts BC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2004 Aug; Vol. 67 (8), pp. 1400-2. |
| DOI: |
10.1021/np049970g |
| Abstrakt: |
During the course of our screening program designed to discover novel anticancer and anti-infective agents from marine microorganisms, a strain of Streptomyces aureoverticillatus (NPS001583) isolated from a marine sediment was found to produce a novel macrocyclic lactam with cytotoxicity against various tumor cell lines. Using extensive MS, UV, and NMR spectral analyses, the structure has been established as compound 1, aureoverticillactam, a 22-atom macrocyclic lactam incorporating both triene and tetraene conjugated olefins. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
