| Autor: |
Abdel Aziz MT; Department of Medical Biochemistry, Faculty of Medicine, University of Cairo, Cairo, Egypt., Abdel-Ghaffar Y, Fouad HH, Abdel Aziz DM, el-Magd AA |
| Jazyk: |
angličtina |
| Zdroj: |
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit [East Mediterr Health J] 2001 Jul-Sep; Vol. 7 (4-5), pp. 779-86. |
| Abstrakt: |
The ratio of stearic to oleic acids, i.e. the fatty acid saturation index, in red blood cell membranes was assayed in 60 patients with chronic hepatitis C virus infection before and after interferon-alpha therapy. Results were compared with 20 healthy controls. Hepatitis C virus titre was also assayed before and after interferon-alpha therapy. Within 2-5 months following interferon-alpha therapy, a significant inverse correlation was observed between saturation index and hepatitis C virus load. We conclude that hepatitis C virus infection enhances the degree of desaturation of 18-carbon fatty acids and that interferon-alpha is involved in their metabolism by increasing the degree of saturation and subsequent decrease in membrane fluidity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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