[Ethnic differences in apolipoprotein B levels in hyperlipidemia in Russian and Kirghiz populations].

Autor:	Mirrakhimov EM, Noruzbaeva AM, Lunegova OS, Afanas'eva MI, Adamova IIu, Pokrovskiĭ SN, Poroshchaĭ EN, Mirrakhimov MM
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2004; Vol. 76 (6), pp. 35-9.
Abstrakt:	Aim: To evaluate the levels of apolipoprotein B (apo-B) and coronary heart disease (CHD) risk factors in Russians and the Kirghiz with primary hyperlipidemia (PHL). Material and Methods: Lipid spectrum of the blood (LDLP and HDLP cholesterol, total cholesterol, triglycerides), apo-B, CHD risk factors were studied in 60 Russian and 75 Kirghis patients with PHL aged 28 to 67 years (mean age 50.0 +/- 7.59 years, 56 females and 79 males). Results: In Russians a mean level of LDLP cholesterol and apo-B was significantly higher than in Kirghiz patients (3.95 +/- 1.29 mmol/l vs 3.51 +/- 1.17 mmol/l, p = 0.042; 173.3 +/- 57.3 mg/dl vs 145.5 +/- 49.3 mg/dl, p = 0.003, respectively). CHD in both ethnic groups occurred with similar rates. The multifactorial regression analysis shows that an apo-B concentration can serve an independent risk factor associated with CHD in the Kirghiz population (beta = 0.25, p = 0.03) while in Russians living in Kirghizia this factor is a low content of HDLP cholesterol (beta = -0.25, p = 0.05).
Databáze:	MEDLINE
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