| Autor: |
García-Martínez LF; Celltech Research & Development, Bothell, WA 98021, USA., Appleby MW, Staehling-Hampton K, Andrews DM, Chen Y, McEuen M, Tang P, Rhinehart RL, Proll S, Paeper B, Brunkow ME, Grandea AG 3rd, Howard ED, Walker DE, Charmley P, Jonas M, Shaw S, Latham JA, Ramsdell F |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2004 Sep 01; Vol. 173 (5), pp. 2995-3001. |
| DOI: |
10.4049/jimmunol.173.5.2995 |
| Abstrakt: |
Using a mouse mutagenesis screen, we have identified CD83 as being critical for the development of CD4(+) T cells and for their function postactivation. CD11c(+) dendritic cells develop and function normally in mice with a mutated CD83 gene but CD4(+) T cell development is substantially reduced. Additionally, we now show that those CD4(+) cells that develop in a CD83 mutant animal fail to respond normally following allogeneic stimulation. This is at least in part due to an altered cytokine expression pattern characterized by an increased production of IL-4 and IL-10 and diminished IL-2 production. Thus, in addition to its role in selection of CD4(+) T cells, absence of CD83 results in the generation of cells with an altered activation and cytokine profile. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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