| Autor: |
Liberman SJ; Comisión Nacional de Energía Atómica (CNEA), Avda. del Libertador 8250, 1429 Buenos Aires, Argentina. liberman@cnea.gov.ar, Dagrosa A, Jiménez Rebagliati RA, Bonomi MR, Roth BM, Turjanski L, Castiglia SI, González SJ, Menéndez PR, Cabrini R, Roberti MJ, Batistoni DA |
| Jazyk: |
angličtina |
| Zdroj: |
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2004 Nov; Vol. 61 (5), pp. 1095-100. |
| DOI: |
10.1016/j.apradiso.2004.05.013 |
| Abstrakt: |
A study of the (10)B-enriched p-boronophenylalanine-fructose complex ((10)BPA-F) infusion procedure in potential BNCT patients, including four melanoma of extremities and two high-grade gliomas (glioblastoma and ganglioglioma) was performed. T/B and S/B ratios for (10)B concentrations in tumor (T), blood (B) and skin (S) were determined. The T/B ratio for the glioblastoma was in the 1.8-3.4 range. The ganglioglioma did not show any significant boron uptake. For the nodular metastasic melanoma T/B values were between 1.5 and 2.6 (average 2.1+/-0.4), corresponding to the lower limit of the mean values reported for different melanoma categories. This result might suggest a lower boron uptake for nodular metastasic melanomas. S/B was 1.5+/-0.4. An open two-compartment pharmacokinetic model was applied to predict the boron concentration during the course and at the end of a BNCT irradiation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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