| Autor: |
de Graaff PM; Division of Pediatrics, The Wilhelmina Children's Hospital, University Medical Center, Utrecht, Netherlands., Heidema J, Poelen MC, van Dijk ME, Lukens MV, van Gestel SP, Reinders J, Rozemuller E, Tilanus M, Hoogerhout P, van Els CA, van der Most RG, Kimpen JL, van Bleek GM |
| Jazyk: |
angličtina |
| Zdroj: |
Virology [Virology] 2004 Sep 01; Vol. 326 (2), pp. 220-30. |
| DOI: |
10.1016/j.virol.2004.06.008 |
| Abstrakt: |
CD4 T cells play a crucial role during virus infections by producing antiviral cytokines and by regulating humoral and cellular immune responses. Unfortunately however, exaggerated CD4 T cell responses can cause significant immune-mediated disease as was observed during RSV infections in children previously vaccinated with a formalin-inactivated virus in the 1960s. It has been observed that vaccination with the G protein of RSV tends to prime mice for a similar Th2-mediated enhanced disease. Whether the G protein may play a role in enhanced disease in man is unclear. In the present study, we identified an immunodominant epitope in the conserved region of the G protein encompassing amino acid residues 162-175. This epitope is presented in the context of HLA-DPB1*0401 and DPB1*0402, the most prevalent HLA class II alleles. Importantly, in some patients, a mixed Th1/Th2 response against this epitope was found in bronchoalveolar lavage samples during primary RSV infections. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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