Synthesis and antiviral activities of new pyrazolo[4,3-c]quinolin-3-ones and their ribonucleoside derivatives.

Autor: de Oliveira MR; Departamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. gqocica@vm.uff.br, Alves TR, Pinto AC, Pereira Hde S, Leão-Ferreira LR, Moussatché N, de Frugulhetti IC, Ferreira VF, de Souza MC
Jazyk: angličtina
Zdroj: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2004 May; Vol. 23 (5), pp. 735-48.
DOI: 10.1081/NCN-120038009
Abstrakt: Several new pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-g) and their corresponding heterocycle moieties (3a-g) were synthesized and evaluated against vaccinia virus (VV) and herpes simplex virus type 1 (HSV-1). The derivatives 3c and 3d showed modest inhibitory activity against vaccinia virus reaching 70% at a concentration of 100 microM. All heterocyclic compounds (3a-f) showed a modest inhibition against HSV-1, reaching the maximal inhibitory effect around 20-30%. The antiviral effects of most of the pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-f) on VV and HSV were not impressive.
Databáze: MEDLINE
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