Malignant thymic carcinoid in multiple endocrine neoplasia type I syndrome: case report and literature review.
| Autor: | Bekele G; Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona 85012, USA., Felicetta JV, Gani O, Shah IA |
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| Jazyk: | angličtina |
| Zdroj: | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists [Endocr Pract] 1998 May-Jun; Vol. 4 (3), pp. 153-8. |
| DOI: | 10.4158/EP.4.3.153 |
| Abstrakt: | Objective: To describe a case of thymic carcinoid tumor in association with multiple endocrine neoplasia type I (MEN I) and discuss the various manifestations of this syndrome. Methods: We present the clinical and laboratory data, including histopathologic and immunocytochemical findings, for our current patient and also review the literature on MEN I syndromes. Results: In a 46-year-old Caucasian man with no family history of multiple endocrine neoplasia, numerous MEN I lesions developed over time. The patient had gastrinoma of the duodenum, Zollinger-Ellison syndrome, hyperparathyroidism, a nonfunctioning adrenal mass, and foregut carcinoid tumors, including gastric and malignant thymic carcinoids. He sequentially underwent partial gastrectomy in conjunction with Billroth II anastomosis, a four-gland parathyroidectomy, and palliative radiotherapy for malignant carcinoid tumor, as well as endoscopic excision of accessible tumors. Conclusion: The involvement in MEN I can be clinically complex. Early detection of MEN I lesions will facilitate timely implementation of treatment and help minimize complications. |
| Databáze: | MEDLINE |
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