| Autor: |
Cofie DQ; Section of Endocrinology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA., Rogers R, Draelos MT, Olansky L, Scofield RH |
| Jazyk: |
angličtina |
| Zdroj: |
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists [Endocr Pract] 1995 Nov-Dec; Vol. 1 (6), pp. 395-8. |
| DOI: |
10.4158/EP.1.6.395 |
| Abstrakt: |
Autoimmune destruction and resultant failure of multiple organ systems constitute an uncommon entity known as type II polyglandular failure. Occasionally, the syndrome is familial, and in the kindreds studied, individual patients have manifested different sets of the associated diseases. We describe a large family in which the presence of HLA-DR4 was associated with development of this syndrome. More commonly, HLA-DR3 has been associated with type II polyglandular failure. The probands are monozygotic twin sisters in whom an identical set of autoimmune diseases occurred in the same order of onset and at approximately the same age. These data suggest that not only do specific factors predispose to this syndrome but also distinct factors determine which individual diseases are expressed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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