[Amoxicillin in tonsillectomy: preliminary data on the evaluation of serum and tissue concentrations].

Autor: Averono G; Clinica Otorinolaringoiatrica, Università degli Studi del Piemonte Orien- tale Amedeo Avogadro, Novara., Olina M, Basile M, Bagnati M, Uglietti A, Garavelli PL, Bellomo G, Pia F
Jazyk: italština
Zdroj: Recenti progressi in medicina [Recenti Prog Med] 2004 Jun; Vol. 95 (6), pp. 314-5.
Abstrakt: Amoxicillin was administered to 50 patients with chronic recurrent tonsillitis waiting for tonsillectomy. Group A (N=16) received 2.2 g of amoxicillin plus clavulanic acid with intravenous injection 10 minutes before tonsillectomy Group B (N=34) was treated with 3 doses of amoxicillin-clavulanic acid administered orally the day before surgery, plus one oral administration 2 hours before tonsillectomy. Antibiotic doses were established on patient's weight using maximum suggested. The measures were, estimated in serum and in tonsils using High Performance Liquid Chromatography, (HPLC). The data show better efficacy of intravenous administration than oral administration.
Databáze: MEDLINE