| Autor: |
Aspinall R; Department of Immunology, Faculty of Medicine, Imperial College, London SW10 9NH, UK. r.aspinall@ic.ac.uk, Henson S, Pido-Lopez J, Ngom PT |
| Jazyk: |
angličtina |
| Zdroj: |
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2004 Jun; Vol. 1019, pp. 116-22. |
| DOI: |
10.1196/annals.1297.021 |
| Abstrakt: |
Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 x 10(11). If the individual has not met the virus before, the response will come from the naive T cell subset (50 +/- 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 10(8) per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (alpha and beta), and the repertoire of specificities is somewhere in the region of 2 x 10(7) to 10(8). A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text