| Autor: |
Russo MT; Department of Environment and Primary Prevention, Istituto Superiore di Sanita', Rome, Italy., De Luca G, Degan P, Parlanti E, Dogliotti E, Barnes DE, Lindahl T, Yang H, Miller JH, Bignami M |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer research [Cancer Res] 2004 Jul 01; Vol. 64 (13), pp. 4411-4. |
| DOI: |
10.1158/0008-5472.CAN-04-0355 |
| Abstrakt: |
The OGG1 and MYH DNA glycosylases prevent the accumulation of DNA 8-hydroxyguanine. In Myh(-/-) mice, there was no time-dependent accumulation of DNA 8-hydroxyguanine in brain, small intestine, lung, spleen, or kidney. Liver was an exception to this general pattern. Inactivation of both MYH and OGG1 caused an age-associated accumulation of DNA 8-hydroxyguanine in lung and small intestine. The effects of abrogated OGG1 and MYH on hepatic DNA 8-hydroxyguanine levels were additive. Because there is an increased incidence of lung and small intestine cancer in Myh(-/-)/Ogg1(-/-) mice, these findings support a causal role for unrepaired oxidized DNA bases in cancer development. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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